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Abstract #1565

Automatic reconstruction of cortico-striato-thalamo-cortical loops with application to obsessive-compulsive disorder

Dogu Baran Aydogan1, David Sean Thylur2, Junyan Wang1, Yuchun Tang3, Janet Sobell1, James Knowles4, and Yonggang Shi1

1Keck School of Medicine of USC, Los Angeles, CA, United States, 2Emory University, Atlanta, GA, United States, 3Shandong University Cheeloo College of Medicine, Shandong, China, 4SUNY Downstate Medical Center, Brooklyn, NY, United States

Cortico-striato-thalamo-cortical (CSTC) loops are thought to play critical roles in the pathophysiology of several brain disorders. Despite the widespread evidence of CSTC circuits' crucial roles in brain disorders, a systematic approach to map their fiber pathways is missing. In order to advance our understanding on these critical circuits and how they are related to brain disorders, we propose a fully automatic approach for the in-vivo reconstruction based on diffusion MRI tractography. To demonstrate our approach, we studied MRI data from 19 patients with obsessive-compulsive disorder and 15 controls. Our approach enables in-dept analysis of the individual connections and also the full CSTC networks of the motor and lateral orbitofrontal loops.

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