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Abstract #1568

Mitigating the effects of imperfect fixel correspondence in Fixel-Based Analysis

Robert Elton Smith1,2 and Alan Connelly1,2

1The Florey Institute of Neuroscience and Mental Health, Melbourne, Australia, 2Florey Department of Neuroscience and Mental Health, The University of Melbourne, Melbourne, Australia

A requisite step in performing a Fixel-Based Analysis (FBA) is the determination of "fixel correspondence", which defines how discrete fibre elements (fixels) for a particular subject map to the fixels defined in each voxel in template space. The method used thus far for this purpose - simply selecting the subject fixel that best aligns with the template fixel - fails to take into consideration the possibility for substantial variations in fixel segmentation across subjects. We propose a more sophisticated algorithm for determining fixel correspondence, which better accounts for differences in fixel segmentation, and demonstrate how this reduces the variance observed in fixel data across healthy controls.

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