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Abstract #1583

Regularized nonnegative least-square fitting for intravoxel incoherent motion data processing: a simulation study

André Monteiro Paschoal1, Renata Ferranti Leoni1, and Fernando Fernandes Paiva2

1InBrain Lab - FFCLRP, University of Sao Paulo, Ribeirao Preto, Brazil, 2Physics Institute of Sao Carlos, University of Sao Paulo, Sao Carlos, Brazil

Fitting model plays a crucial role in the analysis of intravoxel incoherent motion (IVIM) data due to limited number of points and to typical noisy data. Also, injured tissues can change the diffusion coefficient (D) value so that the number of D that contributes to total signal might be unknown. A possible solution for this problem is the nonnegative least-square (NNLS) fitting. This study aimed to evaluate the impact of the parameters used in the fitting and its applicability to simulated IVIM signal data processing.

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