Fitting model plays a crucial role in the analysis of intravoxel incoherent motion (IVIM) data due to limited number of points and to typical noisy data. Also, injured tissues can change the diffusion coefficient (D) value so that the number of D that contributes to total signal might be unknown. A possible solution for this problem is the nonnegative least-square (NNLS) fitting. This study aimed to evaluate the impact of the parameters used in the fitting and its applicability to simulated IVIM signal data processing.
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