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Abstract #1612

Non-Gaussian diffusion restriction effects in intravoxel incoherent motion imaging acquired at b-values below 1000 $$$\tt s/mm^{2}$$$

Hajime Tamura1, Hideki Ota2, Tatsuo Nagasaka2, Naoko Mori2, and Shunji Mugikura2

1Tohoku University School of Medicine, Sendai, Japan, 2Tohoku University Hospital, Sendai, Japan

To know how much the intravoxel incoherent motion (IVIM) parameters deduced by a bi-exponential model are affected by neglecting non-Gaussian diffusion restriction effects, we performed Monte-Carlo simulations: fitting the bi-exponential model to simulated data containing the diffusion restriction effects. The results showed that non-Gaussian diffusion restriction effects may considerably affect estimation of IVIM parameters even when data acquired with low b-values (b≤1000 s/mm2) are used. This should be taken into account when interpreting the results of IVIM analyses based on the bi-exponential model.

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