In the current study, we evaluated the performance of the field-of-view optimized and constrained undistorted single shot (FOCUS) DWI in assessing the optic nerve and chiasma abnormalities of acute optic neuritis. Visual assessment was obtained for the FOCUS-DWI and the conventional-DWI (c-DWI). We found that FOCUS-DWI provided better visual assessments of the optic nerve and chiasma abnormalities in acute optic neuritis (AON), with much reduced blurring effects and geometric deformations. It might indicated that the FOCUS-DWI would improve the diagnostic accuracy and prognosis evaluation in AON.
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