The study intended to investigate the sensitivity of DTI and FDG-PET in 30 patients with early behavioral variant frontotemporal dementia (bvFTD) despite inconspicuous conventional MRI. Based on individual FDG-PET data analysis, 20 patients were rated as bvFTD “typical” with bifrontal/ bitemporal hypometabolism (bvFTD/PET+) and 10 patients as “not typical/normal” (bvFTD/PET-). DTI voxel-based group analyses revealed bifrontal/ bitemporal microstructural degeneration in all patients. However, individual DTI data analysis revealed alterations in only 14%. Neuropsychological symptoms were associated to DTI and FDG-PET identifiable cerebral changes. Summarising improvement of individual DTI analysis tools is necessary to make this technique applicable for clinical routine.