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Abstract #1677

Diagnostic value of diffusion tensor imaging and positron emission tomography in early stages of frontotemporal dementia

Julia Krämer1, Gero Lueg2, Jan-Gerd Tenberge1, Patrick Schiffler1, Alexis Vrachimis3, Matthias Weckesser3, Christian Wenning3, Andreas Johnen1, Matthias Pawlowski1, Sven G. Meuth1, and Thomas Duning1

1Department of Neurology, Westfälische Wilhelms University, Münster, Germany, 2Department of geriatric medicine and early rehabilitation, Marien Hospital Herne, Herne, Germany, 3Department of Nuclear Medicine, Westfälische Wilhelms University, Münster, Germany

The study intended to investigate the sensitivity of DTI and FDG-PET in 30 patients with early behavioral variant frontotemporal dementia (bvFTD) despite inconspicuous conventional MRI. Based on individual FDG-PET data analysis, 20 patients were rated as bvFTD “typical” with bifrontal/ bitemporal hypometabolism (bvFTD/PET+) and 10 patients as “not typical/normal” (bvFTD/PET-). DTI voxel-based group analyses revealed bifrontal/ bitemporal microstructural degeneration in all patients. However, individual DTI data analysis revealed alterations in only 14%. Neuropsychological symptoms were associated to DTI and FDG-PET identifiable cerebral changes. Summarising improvement of individual DTI analysis tools is necessary to make this technique applicable for clinical routine.

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