Diffusion MRI (dMRI) can provide important information about water exchange between different tissue compartments. In this abstract, we introduce a generalized model to measure the exchange rate using arbitrary gradient sequences. We present a unified theory that incorporates water diffusion and exchange as a stochastic diffusion-exchange process. Our work for the first time allows to compare different diffusion sequences and allows to determine the optimal experimental configurations to measure the exchange rate. In the most common situation with single- or double-diffusion encoding (SDE, DDE) sequences, our theory shows that DDE is more sensitive to water exchange at short time scale. We validate our theory using Monte-Carlo simulations.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords