Meeting Banner
Abstract #1685

Obtaining the barrier distribution in the micro-structure from diffusion spectra

Carlos Castillo-Passi1,2, Gabriel Varela-Mattatall1,2, Claudia Prieto1,2,3, Carlos Sing-Long2,4,5, and Pablo Irarrazaval1,2,5

1Department of Electrical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 2Biomedical Imaging Center, Pontificia Universidad Católica de Chile, Santiago, Chile, 3Division of Imaging Sciences and Biomedical Engineering, King’s College London, London, United Kingdom, 4Institute for Computational and Mathematical Engineering, Stanford University, Stanford, CA, United States, 5Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile

Inspired in the solution of the diffusion equation in the restricted case, we propose to express the diffusion $$$q$$$-space information in a restricted basis. This representation allows to obtain the distribution of barriers separations, thus providing useful information about the micro-structure. Previous methods used multiple Diffusion Spectrum Imaging (DSI) images with different diffusion times, which is impractical to characterize barriers in multiple directions. Our method proposes to obtain the barrier distribution with only a single DSI image. Furthermore, the model does not use a strong assumption for the geometry of the barriers (or axons) nor for the probability distribution of the barrier separation.

This abstract and the presentation materials are available to members only; a login is required.

Join Here