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Abstract #1755

A feasibility study of ultra-high-strength gradient system on 3T: demonstration using DTI on anisotropic diffusion fibre phantoms

Ming-Jye Chen1, Kuan-Hung Cho1, Chang-Hoon Choi2, Ezequiel Farrher2, Richard Buschbeck2, Hsuan-Han Chiang1, N. Jon Shah2,3, Hsu Chang1, and Li-Wei Kuo1

1Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Miaoli, Taiwan, 2Institute of Neuroscience and Medicine – 4, Forschungszentrum Juelich, Juelich, Germany, Juelich, Germany, 3Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany

In this study, we aimed to integrate an ultra-high-strength gradient system (15 gauss/cm) on a 3T scanner and to demonstrate its feasibility by employing diffusion tensor imaging (DTI) on dedicated anisotropic diffusion fibre phantoms. Two DTI experiments were performed to explore the feasibility of this gradient system, i.e. comparisons of gradient strengths and number of averages. Our results demonstrate reasonable SNR and diffusion contrast acquired on this system using pulsed gradient spin echo diffusion weighted scans could provide useful information. Consistently, it also suggests higher gradient strength could be beneficial to improve the quality of diffusion MRI experiments and its ability to resolve fibre orientations, especially when higher b-values are used.

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