Abstract #1772

Longitudinal Mapping of Local Relationship of Surface Area, Cortical Thickness and Cortical Folding in Infants

Dingna Duan^1,2, Shunren Xia², Zhengwang Wu¹, Fan Wang¹, Weili Lin¹, John H Gilmore³, Dinggang Shen¹, and Gang Li¹

¹Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China, ³Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

A simple physical law on the global relationship of surface area, cortical thickness, and cortical folding is found across a full range of mammalian species’ brains, including adult human brains^1,2. However, little is known about the local relationship of these cortical properties, especially in infant brains with rapid development in the first two years of life. To fill this knowledge gap, we explored the local relationship of surface area, cortical thickness and cortical folding on 73 normal infants, each of which was longitudinally scanned at 0, 1, and 2 years of age. We reveal that the relationship of these three cortical properties is age-specific and region-specific.

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