Meeting Banner
Abstract #1772

Longitudinal Mapping of Local Relationship of Surface Area, Cortical Thickness and Cortical Folding in Infants

Dingna Duan1,2, Shunren Xia2, Zhengwang Wu1, Fan Wang1, Weili Lin1, John H Gilmore3, Dinggang Shen1, and Gang Li1

1Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou, China, 3Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

A simple physical law on the global relationship of surface area, cortical thickness, and cortical folding is found across a full range of mammalian species’ brains, including adult human brains1,2. However, little is known about the local relationship of these cortical properties, especially in infant brains with rapid development in the first two years of life. To fill this knowledge gap, we explored the local relationship of surface area, cortical thickness and cortical folding on 73 normal infants, each of which was longitudinally scanned at 0, 1, and 2 years of age. We reveal that the relationship of these three cortical properties is age-specific and region-specific.

This abstract and the presentation materials are available to members only; a login is required.

Join Here