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Abstract #1781

Anisotropic similarity, a constrained affine transformation: application to brain development analysis

Antoine Legouhy1, Olivier Commowick1, Fran├žois Rousseau2, and Christian Barillot1

1Univ Rennes, INRIA, CNRS, INSERM, IRISA UMR 6074, VISAGES ERL U-1228, F-35000, Rennes, France, 2IMT Atlantique, LaTIM U1101 INSERM, UBL, Brest, France

The study of brain development provides insights in the normal trend of brain evolution and enables early detection of abnormalities. We propose a method to quantify brain growth in three arbitrary orthogonal directions of the brain through linear registration. We introduce a 9 degrees of freedom transformation that gives the opportunity to extract scaling factors describing brain growth along those directions by registering a database of subjects in a common basis. We apply this framework to create a longitudinal curve of scaling ratios along fixed orthogonal directions from 0 to 16 years highlighting anisotropic brain development.

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