Meeting Banner
Abstract #1795

Investigation of sickle cell related changes in the basal ganglia of pediatric subjects using QSM and R2*.

Richard A Jones1, Binjian Sun1, Deqiang Qiu2, Susan Palasis1, Thomas G Burns1, and Clark Brown3

1Radiology, CHOA, Atlanta, GA, United States, 2Radiology, Emory University, Atlanta, GA, United States, 3Pediatrics, Emory University, Atlanta, GA, United States

In previous work on susceptibility differences between controls and subjects with sickle cell disease (SCD) receiving chronic transfusions we found no significant differences in the basal ganglia (BG). In this abstract we added a group of non-transfused SCD subjects and included an analysis of the R2* in order to better understand the nature of any observed changes. Significant differences between the groups were observed in the BG for both susceptibility and R2*, but the pattern of the changes was inconsistent, probably due to the multifactorial nature of R2* in tissues where iron is not the dominant contrast mechanism.

This abstract and the presentation materials are available to members only; a login is required.

Join Here