Abstract #1797

ROTATING FRAME MRI CONTRASTS FOR ASSESSMENT OF WHITE MATTER ALTERATION IN MUCOPOLYSACCHARIDOSIS TYPE I

Alena Svatkova¹, Bryon A. Mueller², Petr Bednařík³, Carol Nguyen¹, Lubomír Vojtíšek⁴, Silvia Mangia³, Mikko Nissi⁵, Shalom Michaeli³, and Igor Nestrasil¹

¹Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States, ²Department of Psychiatry, University of Minnesota, Minneapolis, MN, United States, ³Radiology, CMRR, University of Minnesota, Minneapolis, MN, United States, ⁴Central European Institute of Technology, Masaryk University, Brno, Czech Republic, ⁵Department of Applied Physics, University of Eastern Finland, Kuopio, Finland

Mucopolysaccharidosis type I (MPSI) is an inherited metabolic disease with severe and attenuated disease subtypes. While both MPSI subtypes manifest pronounced morphological brain changes, little has been discovered about alterations of white matter (WM) microstructure. Here, we utilized rotating frame MRI contrasts along with DTI to detect WM alterations between in 11 severe and 9 attenuated MPSI patients at 3T. T1ρ and RAFF4 detected WM differences between MPS subtypes that were not depicted by DTI. Outcomes demonstrate an exceptional sensitivity of rotating frame methods to probe WM microstructure in MPSI.

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