Abstract #1817

Histoarchitectonically distinct regions of anterior cingulate show altered glutamatergic metabolism in major depressive disorder

Louise Martens^1,2, Felicia von Düring^3,4, Lejla Colic^4,5, Shijia Li⁶, Liliana Ramona Demenescu^4,5, Dominik Denzel^3,4, Inka Ristow^3,4, Matthias Vogel⁷, Sarah Lison⁷, Oliver Speck⁸, Meng Li^2,4,5, and Martin Walter^1,2,4,5,7

¹Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany, ²High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, ³Otto von Guericke University, Magdeburg, Germany, ⁴Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany, ⁵Leibniz Institute for Neurobiology, Magdeburg, Germany, ⁶School of Psychology and Cognitive Science, East China Normal University, Shanghai, China, ⁷Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany, ⁸Biomagnetical Resonance, Otto von Guericke University, Magdeburg, Germany

Increasing evidence suggests a hypoglutamatergic state in major depressive disorder (MDD), however spatial- and metabolite specific abnormalities have not been fully characterized. Using short TE/TM STEAM MRS, we evaluated Glu, Gln, Gln/Glu and GABA metabolism in two histoarchitectonically distinct subdivisions of the anterior cingulate cortex (ACC). The pregenual ACC, involved in emotion processing, showed altered glutamine-glutamine cycling but not altered GABAergic metabolism in MDD, whereas no differences between patients and controls were found in the anteromedial ACC. Increased Gln/Glu in MDD in pgACC but not aMCC confirms a regionally specific role of altered glutamatergic metabolism and neuronal-glial interaction.

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