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Abstract #1817

Histoarchitectonically distinct regions of anterior cingulate show altered glutamatergic metabolism in major depressive disorder

Louise Martens1,2, Felicia von Düring3,4, Lejla Colic4,5, Shijia Li6, Liliana Ramona Demenescu4,5, Dominik Denzel3,4, Inka Ristow3,4, Matthias Vogel7, Sarah Lison7, Oliver Speck8, Meng Li2,4,5, and Martin Walter1,2,4,5,7

1Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany, 2High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tübingen, Germany, 3Otto von Guericke University, Magdeburg, Germany, 4Clinical Affective Neuroimaging Laboratory (CANLAB), Magdeburg, Germany, 5Leibniz Institute for Neurobiology, Magdeburg, Germany, 6School of Psychology and Cognitive Science, East China Normal University, Shanghai, China, 7Department of Psychiatry and Psychotherapy, Otto von Guericke University, Magdeburg, Germany, 8Biomagnetical Resonance, Otto von Guericke University, Magdeburg, Germany

Increasing evidence suggests a hypoglutamatergic state in major depressive disorder (MDD), however spatial- and metabolite specific abnormalities have not been fully characterized. Using short TE/TM STEAM MRS, we evaluated Glu, Gln, Gln/Glu and GABA metabolism in two histoarchitectonically distinct subdivisions of the anterior cingulate cortex (ACC). The pregenual ACC, involved in emotion processing, showed altered glutamine-glutamine cycling but not altered GABAergic metabolism in MDD, whereas no differences between patients and controls were found in the anteromedial ACC. Increased Gln/Glu in MDD in pgACC but not aMCC confirms a regionally specific role of altered glutamatergic metabolism and neuronal-glial interaction.

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