In the present study, diffusion kurtosis imaging (DKI), which is based on the method of voxel-based analysis(VBA), was used to investigate the alterations of microstructure of white matter and gray matter in chronic alcohol dependent patients. Thirty patients with chronic alcohol dependence and twenty healthy volunteers were scanned with DKI. Compared with the healthy control group, the brain regions associated with visual information processing, memory, movement coordination and emotional control capacity have been found to be abnormal in different degrees.
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