The diagnostic utility of Magnetization Transfer Imaging (MTI) was tested in a large cohort of patients with transverse myelitis – a demyelinating myelopathy affecting the spinal cord. We measured the reproducibility of MTI in a pediatric clinical model, at different disease stages. Our results showed that obtaining repeatable measures in the entire spinal cord (C1 to T12) is feasible. Our findings also showed significant differences in MTR values between patients and healthy controls, and between three sub-groups of patients (acute, sub-acute and chronic disease phases).
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