Abstract #1864

Rapid estimation of myelin for diagnostic imaging (REMyDI): A clinical and histopathological validation in multiple sclerosis

Russell Ouellette^1,2,3,4, Marcel Warntjes^5,6, Yngve Forslin^1,2, Michael Plattén^1,2, Martin Uppman¹, Åsa Bergendal^1,7, Fredrik Piehl^1,8, Sten Fredrikson^1,8, Maria Kristoffersen-Wiberg^1,2, Caterina Mainero^3,4, and Tobias Granberg^1,2,3,4

¹Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden, ²Department of Radiology, Division of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden, ³Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁴Harvard Medical School, Boston, MA, United States, ⁵Synthetic MR, Stockholm, Sweden, ⁶Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden, ⁷Department of Medical Psychology, Karolinska University Hospital, Stockholm, Sweden, ⁸Department of Neurology, Karolinska University Hospital, Stockholm, Sweden

Multiple sclerosis is a chronic inflammatory and neurodegenerative disease characterized by demyelination. To follow patients longitudinally and monitor treatment response, there is a need for robust and tissue-specific imaging biomarkers reflective of the heterogeneous disease course. Here, we aimed to validate REMyDI as an MRI-based measure of myelin ex vivo and in vivo. Histopathologically, REMyDI correlates well with all three of the studied myelin staining methods. In vivo, REMyDI revealed a strong sensitivity in differentiating white matter as compared to normal appearing white matter with associations to both cognitive (information processing speed) and physical disability (Expanded Disability Status Scale).

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