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Abstract #1883

Microstructural Characterization of Post-Stroke Lesions in the Posterior Limb of the Internal Capsule in Subacute Patients using DTI and NODDI

Alfonso Mastropietro1, Lucia Fontana2, Maria Luisa Malosio3,4, Laura Straffi5, Simona Marcheselli5, Marco Grimaldi2, and Giovanna Rizzo1

1Institute of Bioimaging and Molecular Physiology, Consiglio Nazionale delle Ricerche, Segrate, Italy, 2Neuroradiology Unit & Neuro Center, Humanitas Clinical and Research Center, Rozzano, Italy, 3Institute of Neuroscience, Consiglio Nazionale delle Ricerche, Milano, Italy, 4Laboratory of Brain Pathology and Pharmacology, Humanitas Clinical and Research Center, Rozzano, Italy, 5Stroke Unit & Neuro Center, Humanitas Clinical and Research Center, Rozzano, Italy

The purpose of his work was to characterize the Posterior Limb of the Internal Capsule (PLIC) of subacute stroke patients using both DTI and NODDI approaches to investigate microstructural changes occurring in the lesioned with respect to the unlesioned hemisphere. Six patients having a brain damage involving the Corticospinal Tract (CST) were enrolled. MRI was carried out on a 3T scanner about 14 days after stroke occurrence. DTI and NODDI analysis showed CST alterations in subacute stroke patients. FA and ODI were the only parameters that underwent significant modifications in PLIC regions.

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Abstract