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Abstract #1892

Intravascular Signal Suppression and Micro-Vascular Signal Mapping obtained from ASL Perfusion Imaging with DANTE Pulse

Yasuhiro Fujiwara1, Hirohiko Kimura2, Shota Ishida3, Masayuki Kanamoto3, Naoyuki Takei4, Tsuyoshi Matsuda5, R Marc Lebel6, and Toshiki Adachi3

1Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan, 2Radiology, University of Fukui, Fukui, Japan, 3Radiological Center, University of Fukui Hospital, Fukui, Japan, 4Global MR Applications and Workflow, GE Healthcare Japan, Tokyo, Japan, 5Division of Ultrahigh Field MRI, Institute for Biomedical Science, Iwate Medical University, Iwate, Japan, 6GE Healthcare, Calgary, Canada

In ASL perfusion imaging, the signal from the label that is still present in larger arteries at the time of imaging causes vascular artifact, which reduces the accuracy of quantification of cerebral blood flow. The purpose of this study is to eliminate the vascular artifacts in larger vessels using the delays alternating with nutation for tailored excitation (DANTE) pulse as vascular crushing gradients and to evaluate the efficiency of the DANTE pulse. The optimized DANTE pulse makes it possible to suppress the vascular signal depending on the flow velocity, which decreased the ASL signal of the arterial region. The relative vascular signal mapping may be helpful to reveal altered hemodynamic state, since the amount of suppressed signal directly associate with flow velocity.

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