In ASL perfusion imaging, the signal from the
label that is still present in larger arteries at the time of imaging causes
vascular artifact, which reduces the accuracy of quantification of cerebral
blood flow. The purpose of this study is to eliminate the vascular artifacts in
larger vessels using the delays alternating with nutation for tailored
excitation (DANTE) pulse as vascular crushing gradients and to evaluate the
efficiency of the DANTE pulse. The optimized DANTE pulse makes it possible to
suppress the vascular signal depending on the flow velocity, which decreased the ASL
signal of the arterial region. The
relative vascular signal mapping may be helpful to reveal altered hemodynamic
state, since the amount of suppressed signal directly associate with flow
velocity.
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