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Abstract #1902

Comparison of Cerebral Blood Flow in a Rat Model of Hypertension and Age-Matched Controls

Abinand C. Rejimon1, Diana Y. Lee1, Rebecca L. McPherson2, Mustapha Bouhrara1, Akshay Naraine2, Kenneth W. Fishbein1, Olga V. Fedorova2, and Richard G. Spencer1

1Laboratory of Clinical Investigation, Magnetic Resonance Imaging and Spectroscopy Section, National Institute on Aging, Baltimore, MD, United States, 2Laboratory of Cardiovascular Sciences, National Institute on Aging, Baltimore, MD, United States

Continuous arterial spin labeling (CASL) was used to quantify and compare cerebral blood flow (CBF) in Dahl salt-sensitive (DSS) and Sprague-Dawley (SD) rats. CBF quantification was greatly facilitated through use of the recently-introduced NESMA non-local noise reduction filter. A blunted response to hypercapnia was observed in the DSS rats. These results demonstrate the dysregulation of cerebral vasodilatory responses in hypertension, and may have important implications in the understanding of the vascular basis for cognitive impairment in humans.

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