Abstract #1918

Pseudo Continuous ASL for Quantification of Regional Cerebral Hypoperfusion in Chronic Fatigue

Deirdre M McGrath¹, Katija Khan^2,3, Annalena Venneri², and Iain D Wilkinson⁴

¹Electronic and Electrical Engineering, University of Sheffield, Sheffield, United Kingdom, ²Department of Neuroscience, University of Sheffield, Sheffield, United Kingdom, ³Department of Clinical Medical Sciences, University of the West Indies, St Augustine, Trinidad and Tobago, ⁴Academic Radiology, University of Sheffield, Sheffield, United Kingdom

In this study pseudo continuous arterial spin labelling (pCASL) was employed to measure cerebral blood flow (CBF) in chronic fatigue syndrome (CFS) patients and healthy volunteers, to determine if CBF was reduced in CFS and in post-exertional malaise. Normalised regional CBF was found to be reduced in CFS for 11 brain regions, predominantly in the left hemisphere, including 8 previously identified regions, along with the left paracentral lobe, and the left and right posterior cingulate. Patients were asked to return for a second scan during post-exertional malaise, in which rCBF was found to be reduced in the left temporal pole.

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