Previous morphometric studies of Parkinson disease (PD) were mainly conducted by measuring gray matter volume and cortical thickness, and little attention has been paid to whether structure MRI improves PD diagnosis or helps differentiating between phenotypes, such as postural instability gait difficulty (PIGD) and tremor dominant (TD). From this study, compared with the control group, PIGD patients had significantly thinning cortical thickness in multiple brain regions, such as bilateral inferiorparietal, paracentral, postiocingulate, superiorfrontal, precuneus, caudalmiddlefrontal, superfrontal and right parsorbitals. TD patients had significantly thinning cortical thickness in left posteriocingulate, inferioparietal and right superiofrontal, superiortemporal, postcentral, precuneus, fusiform and parahippacampal . In addition, subcortical volume atrophy was identified in the bilateral hippocampus and bilateral amygdala of the patients with PIGD, only little bilateral hippocampus changes was found in the TD group.
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