Parkinson’s disease (PD) is one of the most common neurodegenerative disorders worldwide. This study explores the relationships between iron accumulation in different nucleus, including red nucleus (RN), caudate nucleus (CN), global pallidus (GP), putamen (PUT), and the severity of PD, which is characterized by the Unified Parkinson’s Disease Rating Scale (UPDRS)-III. Significant bilateral difference was found in RN only. Significant correlations were found in bilateral GPe, PUT, RN, and contralateral GPi, which can serves as an evidence that iron deposition can be an important biomarker for the severity of PD.
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