Parkinson's disease is the most common extrapyramidal disease in the elderly people, and the overall prevalence rate is increasing year by year. Diffusion kurtosis imaging (DKI) which was an based on the extension of diffusion tensor imaging (DTI) to reflect the diffusion motion of water molecules in the non-Gaussian distribution between tissues have been proved reliable for the brain microstructural changes. Previous studies have shown that DKI could facilitate the detection of subtle structural changes in the gray matter nuclei of patients with PD, which may be related to the reduction of dopaminergic neurons, iron deposition and gliosis.
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