Abstract #1963

MRI Assessment of SPION Contrast in the Inner Ear

Wendy Oakden¹, Maya Kuroiwa Rivero^2,3, Lola Awofala³, Greg J Stanisz^1,4,5, and Trung N Le^2,3

¹Physical Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ²Department of Otolaryngology Head & Neck Surgery, University of Toronto, Toronto, ON, Canada, ³Biological Sciences Platform, Sunnybrook Research Institute, Toronto, ON, Canada, ⁴Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Lublin, Poland

A novel approach to diagnostic imaging and treatment of the inner ear disorders is magnetic targeting of therapy using superparamagnetic iron oxide nanoparticles (SPIONs). SPIONs were deposited onto the round window niche using a surgical approach, and then magnetic targeting was used, in the treatment group, to “pull” the SPIONs further into the inner ear. High resolution T2 weighted imaging was used to assess the treatment. Signal loss was observed in the vestibule and cochlea in both groups, while increased signal loss was observed at the apex of the cochlea in treated animals relative to the control group.

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