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Abstract #1975

Cortical metabolic changes and glial cell activation in multiple sclerosis: An in vivo 11C-PBR28 MR-PET and magnetic resonance spectroscopy study.

Elena Herranz1,2, Constantina Andrada Treaba1,2, Eva Ratai1,2, Valeria Barletta1,2, Russell Ouellette1, Marco Loggia1,2, Jacob Sloane2,3, Eric Klawiter1,2,4, and Caterina Mainero1,2

1Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Harvard Medical School, Boston, MA, United States, 3Neurology, Beth Israel Deaconess Medical Center, Boston, MA, United States, 4Neurology, Massachusetts General Hospital, Boston, MA, United States

We combined 11C-PBR28 imaging on a high resolution, integrated human MR-PET system with magnetic resonance spectroscopy to investigate brain metabolites abnormalities and microglia activation in the motor cortex of multiple sclerosis subjects relative to healthy controls. Our study provided increase of microglia activation and decrease of N-acetylaspartate, the latter indicating neuronal injury and/or loss, in multiple sclerosis compared to controls. None of the other metabolites (choline, myoinositol, glutamine, glutamate, phosphocholine) showed significant differences between the two groups. Also, we did not find a correlation between 11C-PBR28 binding and the metabolites concentration, suggesting that the two measures reflect distinct pathological aspects.

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