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Abstract #1982

Evolution of functional and structural connectivity of motor network during 2 years of fingolimod therapy for multiple sclerosis

Pallab K Bhattacharyya1,2, Robert Fox3, Hong Li4, Jian Lin1, Ken E Sakaie1, and Mark J Lowe1

1Imaging Institute, Cleveland Clnic, Cleveland, OH, United States, 2Radiology, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, United States, 3Neurological Institute, Cleveland Clnic, Cleveland, OH, United States, 4Quantitative Health Sciences, Cleveland Clnic, Cleveland, OH, United States

Evolution of resting state functional connectivity (fcMRI) between right and left primary motor cortices, and structural connectivity along corticospinal tract (CST) during 2 years of Filgolimod therapy of patients with multiple sclerosis were investigated. MS patients were scanned at baseline (just prior to start of treatment), 6, 12, 18 and 24 months after the start of treatment. Using echoplanar imaging for fcMRI and high angular resolution diffusion imaging for assessing normal appearing white matter integrity along CST, it was found that both functional and structural connectivity damage of motor network stabilized after one year of fingolimod treatment.

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