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Abstract #1987

The corticospinal tract in relapsing-remitting multiple sclerosis: a preliminary tractography and fixel-based MRI analysis at ultra high-field

Myrte Strik1, Camille Shanahan1, Stacey Telianidis 1, Anneke Van der Walt 2,3, Rebecca Glarin1, Roger Ordidge1, Bradford Moffat1, Fary Khan3, Andisheh Bastani3, Eduardo Cofré Lizama3, Mary Galea3, Trevor Kilpatrick1,2, Jon Cleary1, and Scott Kolbe1,4

1Anatomy and Neuroscience, University of Melbourne, Melbourne, Australia, 2Neurology, Royal Melbourne Hospital, Melbourne, Australia, 3Medicine, University of Melbourne, Melbourne, Australia, 4Florey Institute of Neuroscience and Mental Health, Melbourne, Australia

Lower limb disability in multiple sclerosis (MS) is likely related to axonal damage in the corticospinal tract (CST), the main motor pathway. This study aimed to compare the degree of CST degeneration to clinical motor disability using high field (7T) diffusion weighted MRI and subsequent analyses methods like tractography and fixel-based analysis. Eleven minimally impaired relapsing-remitting MS patients (1m/10f, 42±12.4yrs) were tested. Results show loss of fiber density (FD) in the subcortical white matter of the CST was associated with increased pyramidal dysfunction (puncorrected<0.05). FD could provide a useful marker of disease progression leading to loss of mobility.

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