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Abstract #2014

Quantitative vascular measurements in APOE-ε4 knock-in female rats before the onset of AD

Codi Gharagouzloo1, Praveen Kulkarni2, Liam Timms3, Ju Qiao3, Srinivas Sridhar3, and Craig Ferris2

1Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, 2Center for Translational Neuroimaging (CTNI), Northeastern University, Boston, MA, United States, 3Nanomedicine Science and Technology Center, Northeastern University, Boston, MA, United States

There is an increasing body of evidence that suggests vascular dysfunction may play an important role in Alzheimer’s Disease (AD)1. Hyperperfusion has been shown to be associated with mild cognitive impairment (MCI) and hypoperfusion with the onset of AD, along with neurodegeneration2,3. In this study we utilized a novel imaging modality, QUTE-CE MRI4,5, to study the micro- and macro- vascular abnormalities in a APOE-ε4 knock-in model, since the APOE-ε4 allele is the single most important genetic risk factor for AD. While our 173-region characterization reveals both hyper- and hyop-vascularization, the changes in microvascularity are almost entirely hypervascular.

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