Abstract #2021

Increased Mode of Anisotropy in crossing-fibre areas predicts conversion from Mild Cognitive Impairment (MCI) to Alzheimer's disease (AD)

Matt C Gabel¹, Meena Zaveri², Laura Serra³, Marco Bozzali^1,3, and Mara Cercignani¹

¹Clinical Imaging Sciences Centre, Brighton and Sussex Medical School, Brighton, United Kingdom, ²School of Life Sciences, University of Sussex, Falmer, United Kingdom, ³Neuroimaging Laboratory, Santa Lucia Foundation IRCCS, Rome, Italy

Diffusion MRI was used to examine whether any change in the white matter tracts of patients with mild cognitive impairment (MCI) can predict conversion to Alzheimer’s disease (AD) in a longitudinal study. Our data show increases in mode of anisotropy (MO) in a region of crossing fibres in the centrum semiovale for MCI patients who later converted to AD.

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