Abstract #2030

MRI Hippocampal subfield volume analysis: Comparison between Alzheimer's disease, mild cognitive impairment, and normal aging subjects in an amyloid PET project.

Natcha Wontaneeporn¹, Chanon Ngamsombat¹, Weerasak Muangpaisan², Panida Charnchaowanish¹, and Orasa Chawalparit¹

¹Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ²Department of Geriatric Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

Hippocampal atrophy evidenced by MRI is one of the most validated biomarkers of Alzheimer’s disease (AD). The previous neuropathological data showed a differential vulnerability of hippocampal subfields to AD processes. This study aims to use an automated analysis technique for subfield hippocampal volume measurement in order to differentiate early detection of AD. We demonstrated high diagnostic efficacy of using hippocampal subfield analysis for discriminating AD subjects from heathy control (HC) or mild cognitive impairment (MCI) than whole hippocampal volume and feasibility for discriminating MCI to HC as compared with amyloid PET result.

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