Abstract #2040

Improving sensitivity of infiltrative glioma detection by multi-parametric magnetic resonance imaging

Georgia Kanli^1,2, Anaïs Oudin^1,2, Simone P. Niclou^2,3, Rolf Bjerkvig^2,3,4, and Olivier Keunen^1,2

¹In Vivo Imaging Facility, Department of Oncology, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg, ²NorLux Neuro-Oncology Laboratory, Department of Oncology, Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg, ³KG Jebsen Brain Tumour Research Center, Department of Biomedicine, University of Bergen, Bergen, Norway, ⁴NorLux Neuro-Oncology, Department of Biomedicine, University of Bergen, Bergen, Norway

Glioblastoma is characterized by poor prognosis and limited treatment efficacy. One main contributing factor is the presence of a large population of infiltrated tumor cells that are difficult to visualize and treat with resective surgery and radiochemotherapy. In the present study, we aim at establishing techniques that combine various contrast mechanisms available in MRI and PET to improve the sensitivity of the detection of infiltrated tumour cells. Such techniques are likely to improve prognosis by early tumor detection, better delineation of the target for radiotherapy, and better assessment of the full extent of the tumor and its response to therapy.

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