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Abstract #2049

A Simplified Method to Estimate Perfusion Characteristics of Gliomas based on Diffusion-weighted Imaging

Mengqiu Cao1, Shiteng Suo1, Xu Han1, Yawen Sun1, Yao Wang1, Weina Ding1, Ke Jin2, Xiaohua Zhang2, Jianxun Qu3, and Yan Zhou1

1Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China, Shanghai, China, 2Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China, Shanghai, China, 3GE Healthcare China, Shanghai, P.R. China, Shanghai, China

The purpose of the study was to evaluate the application of a simplified method to estimate the perfusion characteristics of glioma as an alternative less time-consuming approach. Fifty patients confirmed with glioma were assessed with multi-b-value DWI and DCE MR imaging. Results indicated that the simplified perfusion fraction (SPF) based on DWI acquired with three b-values showed strong correlation with IVIM-derived f and D*, and showed medium correlation with DCE MR imaging-derived Ktrans and vp. SPF achieved the highest accuracy for gliomas grading. SPF may serve as a valuable alternative to measure tumor perfusion in gliomas.

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