The purpose of the study was to evaluate the application of a simplified method to estimate the perfusion characteristics of glioma as an alternative less time-consuming approach. Fifty patients confirmed with glioma were assessed with multi-b-value DWI and DCE MR imaging. Results indicated that the simplified perfusion fraction (SPF) based on DWI acquired with three b-values showed strong correlation with IVIM-derived f and D*, and showed medium correlation with DCE MR imaging-derived Ktrans and vp. SPF achieved the highest accuracy for gliomas grading. SPF may serve as a valuable alternative to measure tumor perfusion in gliomas.