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Abstract #2051

Distortion-Free Imaging: A Double Encoding Method (DIADEM), High-Resolution Diffusion Imaging of Brain Tumors on a Compact 3T Scanner

Myung-Ho In1, Joshua D Trzasko1, Yunhong Shu1, Shengzhen Tao1, Erin M Gray1, Matt A Bernstein1, and John Huston1

1Department of Radiology, Mayo Clinic, Rochester, MN, United States

Recently, we developed a multi-shot method using spin-warp echo-planar encoding technique inspired by point-spread function mapping. Distortion-free imaging: a double encoding method (DIADEM) can achieve distortion-free, very high in-plane spatial resolution whole brain diffusion imaging in less than 10 minutes on a compact 3T scanner with high performance gradients. A clinical feasibility study of brain tumor diffusion imaging was performed to explore the efficacy of this approach compared to standard single-shot, echo-planar imaging commonly used in clinical practice. The results demonstrate that the proposed method allows considerable improvements in characterizing brain tumors especially at regions of the brain typically degraded by high susceptibility artifacts.

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