Stress is a potent modulator of brain metabolism and function. Here we use a combined approach of blood corticosterone quantification, nuclear magnetic resonance spectroscopy and resting state functional magnetic resonance imaging to probe both metabolic and functional changes in the brain. We show correlations in the concentration of GABA/Glutamine and Glutamate/Glutamine in the hippocampus and how these two factors interact with the response to stress. Furthermore we explore how the changes in neurotransmitters correlate with functional networks, revealing several affected connections especially with the retrosplenial cortex, therefore suggesting a role of this relationship in the affected memory phenotype.
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