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Abstract #2062

Linking neurotransmitter concentration and functional connectivity of the hippocampus after stress: an in-vivo MRI study

Ricardo Magalhães1,2, David Barriére3, Ashley Novais1,2, Fernanda Marques1,2, João Carlos Sousa1,2, João Cerqueira1,2, Arnaud Cachia3,4, Thérèse Jay3, Nuno Sousa1,2, Sébastien Mériaux5, and Fawzi Boumezbeur5

1Life and Health Sciences Institute, ICVS, School of Medicine, Universidade do Minho, Braga, Portugal, 2ICVS/3B's - PT Government Associate laboratory, Braga/Guimaraes, Portugal, 3Physiopathologie des Maladies Psychiatriques, UMR_S 894 Inserm, Paris, France, 4Univ. Paris Descartes, Paris, France, 5Neurospin, JOLIOT, CEA, Paris, France

Stress is a potent modulator of brain metabolism and function. Here we use a combined approach of blood corticosterone quantification, nuclear magnetic resonance spectroscopy and resting state functional magnetic resonance imaging to probe both metabolic and functional changes in the brain. We show correlations in the concentration of GABA/Glutamine and Glutamate/Glutamine in the hippocampus and how these two factors interact with the response to stress. Furthermore we explore how the changes in neurotransmitters correlate with functional networks, revealing several affected connections especially with the retrosplenial cortex, therefore suggesting a role of this relationship in the affected memory phenotype.

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