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Abstract #2064

Retinal Vascular Fractal Dimension and Cerebral Blood Flow, a pilot study

Jeremy Nadal1,2, Jeremy Deverdun3, Nicolas Menjot de Champfleur3, Emmanuelle Le Bars3, and Vincent Daien4,5

1Department of Ophthalmology, Nîmes University Hospital, Nimes, France, 2Gui de Chauliac Hospital, I2FH, Institut d'Imagerie Fonctionnelle Humaine, Montpellier, France, 3Neuroradiology, I2FH - CHU Gui de Chauliac, Montpellier, France, 4U1061, INSERM, Montpellier, France, 5Department of Ophthalmology, Gui De Chauliac Hospital, Montpellier, France

The retinal vascular fractal dimension (FD) is a marker of retinal vascular complexity of the vascular tree. It has been associated with systemic disorders but also with neurodegenerative and cerebrovascular diseases. The purpose of this study was to explore the relationship between cerebral blood flow (CBF), retinal vascular FD and other retinal vascular markers. CBF was estimated in vascular territories using 2D PASL sequence. CBF was positively associated to venular FD (R2=0.32, p=0.03). Non-invasive exploration of the retinal vasculature may be used as a proxy measure, with the condition of retinal vessels possibly reflecting the condition of the cerebral vasculature.

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