Abstract #2064

Retinal Vascular Fractal Dimension and Cerebral Blood Flow, a pilot study

Jeremy Nadal^1,2, Jeremy Deverdun³, Nicolas Menjot de Champfleur³, Emmanuelle Le Bars³, and Vincent Daien^4,5

¹Department of Ophthalmology, Nîmes University Hospital, Nimes, France, ²Gui de Chauliac Hospital, I2FH, Institut d'Imagerie Fonctionnelle Humaine, Montpellier, France, ³Neuroradiology, I2FH - CHU Gui de Chauliac, Montpellier, France, ⁴U1061, INSERM, Montpellier, France, ⁵Department of Ophthalmology, Gui De Chauliac Hospital, Montpellier, France

The retinal vascular fractal dimension (FD) is a marker of retinal vascular complexity of the vascular tree. It has been associated with systemic disorders but also with neurodegenerative and cerebrovascular diseases. The purpose of this study was to explore the relationship between cerebral blood flow (CBF), retinal vascular FD and other retinal vascular markers. CBF was estimated in vascular territories using 2D PASL sequence. CBF was positively associated to venular FD (R2=0.32, p=0.03). Non-invasive exploration of the retinal vasculature may be used as a proxy measure, with the condition of retinal vessels possibly reflecting the condition of the cerebral vasculature.

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