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Abstract #2082

Daily Pain in Adults with Sickle Cell Disease is Associated with Alterations in Functional Connectivity of the Brain

Guangyu Chen1, Arun Singavi1, Nancy Wandersee2, Collin Hubler2, Amanda Brandow1, Simpson Pippa1,2, Shi-Jiang Li1, and Joshua Field1,2

1Medical College of Wisconsin, Milwaukee, WI, United States, 2BloodCenter of Wisconsin, Milwaukee, WI, United States

About half of Sickle Cell Disease (SCD) adults suffer from a chronic pain syndrome. What of the SCD brain contributes to the development and maintenance of the pain syndrome is unknown. We used resting state functional connectivity MRI (rfcMRI) technique, found significant differences between SCD and controls in areas known to contribute to the development and maintenance of a chronic pain syndrome, and the differences have significant associations with the pain phenotype measurements. The findings suggest that rfcMRI could be used as a biomarker to determine the efficacy of interventions targeted to chronic pain in SCD patients.

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