Abstract #2087

Observing the Hyaluronan Component of the Extracellular Matrix in the Brain with Quantitative MRI

Riccardo Metere¹, Carsten Jäger^2,3, Markus Morawski³, and Harald E. Möller¹

¹NMR Unit, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ³Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany

The tissue composition of the brain can be related to different contrast sources in quantitative MRI. Notably, T₁ and T₂^* strongly correlate with myelin and iron. However, other components may play a role in contrast generation. In particular, the hyaluronan component of the extracellular matrix has been recently proposed as a possible important contributor to MRI contrast. Here, we quantify the bulk contribution of hyaluronan to quantitative relaxation maps. This is obtained by characterizing the evolution of the relevant MRI parameters over time during the enzymatic digestion of the hyaluronan.

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