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Abstract #2089

Towards an optimized protocol for dynamic oxygen enhanced imaging of the brain.

William Lloyd1, Adam K Featherstone1, Alan Jackson1, and Geoff JM Parker1

1University of Manchester, Manchester, United Kingdom

T1w dynamic oxygen-enhanced MRI (OE-MRI) has been shown to be a promising method for the assessment and quantification of tumour hypoxia. This work presents a comparison between two possible methods; FFE and IR-TFE based sequences. IR-TFE is shown to give greater contrast for oxygen induced signal change as well as increased SNR. Further sequence optimisation demonstrates the possibility of scanning at high resolution while maintaining contrast and SNR.

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