Meeting Banner
Abstract #2110

Vitamin B12 Deficiency Perturbed Energy Metabolism in Pre Frontol Cortex: 1H-[13C] NMR Study

Anant Bahadur Patel1, Jitendra Kumar Sinha2, Shampa Ghosh2, TK Sampath Kumar 1, and Manchala Raghunath2

1NMR Microimaging and Spectroscopy, Centre for Cellular and Molecular Biology, Hyderabad, India, 2National Institute of Nutrition, Hyderabad, India

The consequences of severe deficiencies in micronutrients especially vitamin B12 on the developing brain during infancy and early post-natal period is not very clear. The current study aim to understand the effects of B12 deficiency on cognitive function using 1H-[13C]-NMR spectroscopy together with [1,6-13C2]glucose infusion in vitamin B12 deficient mice. Our findings indicate reduction in the metabolic activity of glutamatergic and GABAergic neurons in the prefrontal cortex of mice maintained with moderate and severe vitamin B12 defcient diet.

This abstract and the presentation materials are available to members only; a login is required.

Join Here