The consequences of severe deficiencies in micronutrients especially vitamin B12 on the developing brain during infancy and early post-natal period is not very clear. The current study aim to understand the effects of B12 deficiency on cognitive function using 1H-[13C]-NMR spectroscopy together with [1,6-13C2]glucose infusion in vitamin B12 deficient mice. Our findings indicate reduction in the metabolic activity of glutamatergic and GABAergic neurons in the prefrontal cortex of mice maintained with moderate and severe vitamin B12 defcient diet.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords