Abstract #2112

Physical exercise enhances adult cortical plasticity in neonatal hypoxic ischemic injured rats: Evidence by BOLD-fMRI and LFP electrophysiological recording

Sun Young Chae^1,2, Jun Ho Jang³, Geun Ho Im^4,5, Moon-sun Jang^4,5, Won-Beom Jung^2,6, Seungsoo Chung⁷, and Jung Hee Lee^1,2,4,6

¹Department of Health Sciences and Technology, SAIHST, Sungkyunkwan university, Seoul, Republic of Korea, ²Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, Republic of Korea, ³BnH Research co.,Ltd, Goyang, Republic of Korea, ⁴Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea, ⁵Center for Molecular and Cellular Imaging, Samsung Biomedical Research Institute, Seoul, Republic of Korea, ⁶Department of Global Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, ⁷Department of Physiology, Yonsei University Colleage of Medicine, Seoul, Republic of Korea

The developing brain has a powerful ability to modify its own structure and function for recovery from injury in efforts to compensate for loss of function^1,2. In critical period, developing brain has maximal neuronal synaptic connections so it is most amenable to changes in response to external stimulus such as physical exercise³. However, after critical period, neuronal synaptic connections are reduced, and maintained at the reduced state³. Here, we demonstrate enhanced neuroplasticity with physical exercise performed beyond critical period for rats that are injured during critical period. We obtained the BOLD-fMRI response and the interneuron activity with LFP electrophysiological recording.

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