Abstract #2119

Protective effect of high creatine diet during chronic hepatic encephalopathy in young rats, an in vivo longitudinal 1H and 31P MRS study

Veronika Rackayova¹, Olivier Braissant², Dario Sessa³, Stefanita Mitrea⁴, Valerie McLin³, Rolf Gruetter⁴, and Cristina Cudalbu⁴

¹Laboratory of Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ²Neurometabolic Unit, Service of Clinical Chemistry, University Hospital of Lausanne, Lausanne, Switzerland, ³Swiss Center for Liver Disease in Children, University Hospitals Geneva, Geneva, Switzerland, ⁴Centre d’Imagerie Biomédicale (CIBM), Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

Chronic hepatic encephalopathy(CHE) is a serious neuropsychiatric disease with altered neurological status and changes in brain metabolites (among others, decrease in brain tCr). If CHE is acquired in childhood these conditions might perturb normal brain development. Our aim was to test whether oral Cr supplementation dampens the neurometabolic changes observed in CHE in a longitudinal model of chronic liver disease in young rats. Using in vivo longitudinal brain 1H and 31P-MRS, we showed rescued tCr levels, enhanced energy metabolism (restoration of ATP), improved antioxidant capacity (increased Asc), positive effect on phospholipid metabolism and smaller increase in Gln (marker of CHE).

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