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Abstract #2133

Volume-independent radiomic features from T2w-FLAIR MRI could reveal mutation of histones in diffuse intrinsic pontine glioma

Jessica Goya-Outi1, Fanny Orlhac1, Raphael Calmon2, Cathy Philippe3, Stéphanie Puget4, Nathalie Boddaert2, Irène Buvat1, Jacques Grill5, Vincent Frouin3, and Frédérique Frouin1

1IMIV, Inserm, CEA, CNRS, Université Paris-Sud, Université Paris-Saclay, Orsay, France, 2Pediatric Radiology, Hôpital Necker Enfants Malades, AP-HP, Paris, France, 3UNATI, Neurospin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France, 4Pediatric Neurosurgery, Hôpital Necker Enfants Malades, AP-HP, Paris, France, 5Cancérologie de l'enfant et de l'adolescent, Gustave Roussy, CNRS UMR 8203, Université Paris-Saclay, Villejuif, France

In diffuse intrinsic pontine glioma, the mutations of histones (H3.1 versus H3.3) are correlated with patient survival. A new method to compute radiomic features free of tumor volume effect was applied to four structural MR modalities and patients were classified according to histone mutation. The tumor was scanned by a 5 mm radius sphere and textural indices were computed inside each position. A total of 37 features calculated from T2w-FLAIR yielded an area under the Receiver Operating Characteristics curve greater than 0.85. T2w-FLAIR appears to be the most informative modality to predict mutation type.

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