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Abstract #2151

Comparison of R2* and quantitative susceptibility mapping in the characterizing tumor hypoxia in a mouse model of glioblastoma

Runze Yang1, A. Max Hamilton1, Hongfu Sun1, Susobhan Sarkar2, Reza Mirzaei2, G. Bruce Pike1, V. Wee Yong2, and Jeff F. Dunn1

1Radiology, University of Calgary, Calgary, AB, Canada, 2Clinical Neuroscience, University of Calgary, Calgary, AB, Canada

Hypoxia (low levels of oxygen) is an important biomarker in many solid tumors, as it is responsible for promoting tumor angiogenesis and resistance to radiotherapy. Hypoxia can be indirectly monitored by measuring levels of deoxyhemoglobin with MRI, using either R2* or quantitative susceptibility mapping (QSM). We compared the two methods for brain tumor and hypoxia imaging in a mouse model of glioblastoma. We found that both methods were sensitive at detecting a decrease in deoxyhemoglobin due to 100% oxygen. However, QSM provided better anatomical information and was better at detecting tumor heterogeneity. QSM is a promising tumor imaging method.

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