DWI showed great potential for estimation of histopathological and molecular profile of human glioma. 97 patients with suspected glioma underwent pre-operative MRI-scans, including high b-value DWI. ADC-maps from pairs of two b-values were calculated. Post-interventional histopathological tumor grading was realized on a molecular basis using the molecular markers IDH-mutation, 1p/19q- and ATRX-loss. Significant differences (p < 0.001) were found between oligodendroglioma, astrozytoma and GBM. Best discrimination was achieved when calculating the ADC-maps from b-values of 500 and 2500 s/mm2. Therefore, ADC-map based evaluation of glioma in DWI provides great potential in accurate pre-interventional diagnosing of glioma subtypes.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords