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Abstract #2156

ADC-map-based classification of glioma-subtypes in diffusion-weighted MR-Imaging

Nils Christoph Nuessle1, Johann Martin Hempel1, Jens Schittenhelm2, and Uwe Klose1

1Department for Neuroradiology, University Hospital of Tuebingen, Tuebingen, Germany, 2Institute of Neuropathology, Department of Pathology and Neuropathology, University Hospital of Tuebingen, Tuebingen, Germany

DWI showed great potential for estimation of histopathological and molecular profile of human glioma. 97 patients with suspected glioma underwent pre-operative MRI-scans, including high b-value DWI. ADC-maps from pairs of two b-values were calculated. Post-interventional histopathological tumor grading was realized on a molecular basis using the molecular markers IDH-mutation, 1p/19q- and ATRX-loss. Significant differences (p < 0.001) were found between oligodendroglioma, astrozytoma and GBM. Best discrimination was achieved when calculating the ADC-maps from b-values of 500 and 2500 s/mm2. Therefore, ADC-map based evaluation of glioma in DWI provides great potential in accurate pre-interventional diagnosing of glioma subtypes.

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