The blood-brain partition coefficient (BBPC) is a tissue-specific parameter important in quantifying cerebral blood flow (CBF), but regional differences in BBPC are commonly ignored. Using an accelerated calibrated proton density imaging technique we measure BBPC directly, enabling a voxel-wise correction of CBF maps derived from arterial spin labeling acquisitions. We measure an elevated BBPC in the cortex (0.99mL/g) relative to the corpus callosum (0.93mL/g) and the hippocampus (0.95mL/g), and demonstrate that BBPC-correction improves gray-white matter contrast in CBF maps by 15% in the cortex and 7% in the hippocampus.
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