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Abstract #2174

Investigating Cerebrovascular Reactivity Using Pseudo-continuous ASL and Turbo QUASAR ASL at Varying Blood Flow Conditions

Moss Y Zhao1, Lena Vaclavu2, Esben T Petersen3, Henk-Jan Mutsaerts2,4,5, Bart J Biemond6, Ed T van Bavel7, Charles B Majoie2, Aart J Nederveen2, and Michael A Chappell1

1Institute of Biomedical Engineering, University of Oxford, Oxford, United Kingdom, 2Department of Radiology and Nuclear Medicine, Academic Medical Center, Amsterdam, Netherlands, 3Danish Research Centre for Magnetic Resonance, Copenhagen, Denmark, 4Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands, 5Rochester Institute of Technology, Rochester, NY, United States, 6Department of Haematology, Academic Medical Center, Amsterdam, Netherlands, 7Department of Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

CVR has become an important biomarker to assess cerebrovascular health, and ASL is a non-invasive technique to quantify CVR. This work compared the CVR measurement from PCASL and Turbo QUASAR ASL at varying blood flow conditions induced by acetazolamide. Results showed that both ASL techniques were sensitive to CVR and that significant changes of ATT were detected by Turbo QUASAR ASL. The differences in CVR (higher in PCASL) may be due to the different sensitivity to ATT of the two ASL methods.

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