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Abstract #2176

Regional Oxygen Extraction Fraction Measurements in the Middle Cerebral Artery Territory using Selective Localised T2-Relaxation-Under-Spin-Tagging (SL-TRUST)

Caitlin O'Brien1, Thomas Okell1, and Peter Jezzard1

1Wellcome Centre for Integrative Neuroimaging, FMRIB, University of Oxford, Oxford, United Kingdom

Regional measurements of brain tissue oxygen extraction fraction (OEF) are an important indicator of tissue physiology and disease. We present an improved Selective Localised T2-relaxation-under-spin-tagging (SL-TRUST) sequence for regional venous blood T2 measurements, decoded in the superior sagittal sinus, from which cerebral tissue OEF can be calculated. A spatially selective WET saturation scheme is used to saturate signal outside the region of interest, enabling OEF measurements in a hemisphere and in the middle cerebral artery (MCA) territory. Using a multi-TI inversion recovery sequence we calculate subject specific blood hematocrit in the sagittal sinus and thus improve our OEF calibration.

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