Regional measurements of brain tissue oxygen extraction fraction (OEF) are an important indicator of tissue physiology and disease. We present an improved Selective Localised T2-relaxation-under-spin-tagging (SL-TRUST) sequence for regional venous blood T2 measurements, decoded in the superior sagittal sinus, from which cerebral tissue OEF can be calculated. A spatially selective WET saturation scheme is used to saturate signal outside the region of interest, enabling OEF measurements in a hemisphere and in the middle cerebral artery (MCA) territory. Using a multi-TI inversion recovery sequence we calculate subject specific blood hematocrit in the sagittal sinus and thus improve our OEF calibration.
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