A key issue in cerebral perfusion imaging is the selection of an arterial input function (AIF). AIF shape-properties have been used as criteria for automatic AIF selection. This study compares three brain regions for AIF target areas. The Middle Cerebral Artery (MCA) -M1 segment, the MCA-vascular territory and whole-brain. The prior displayed high noise levels, while the latter produced AIFs delayed compared to GM/WM tissue. The MCA-vascular territory is suggested as a region of interest for automatic AIF detection
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