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Abstract #2203

Nonlinear projection onto dipole fields with preconditioning (nPDF)

Carlos Milovic1,2, Berkin Bilgic3, Bo Zhao3, Christian Langkammer4, Julio Acosta-Cabronero5, and Cristian Tejos1,2

1Department of Electrical Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile, 2Biomedical Imaging Center, Pontificia Universidad Catolica de Chile, Santiago, Chile, 3Martinos Center for Biomedical Imaging, Harvard Medical School, Charlestown, MA, United States, 4Department of Neurology, Medical University of Graz, Graz, Austria, 5Wellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, London, United Kingdom

QSM requires to remove fields originated outside a region of interest prior to inversion. This is prone to generating artifacts due to noise and error propagation from previous processing steps such as coil combination or phase unwrapping. To address this, we reformulated the widely used projection onto dipole fields (PDF) method as a nonlinear problem with pre-conditioning. This new formalism is wrap-insensitive, results in improved noise/error management, and might enable a more straightforward implementation of multi-coil/-echo combination and background removal steps into a single optimizer.

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